PSA Test Risks: What You Need to Know Before Getting Screened

When it comes to PSA test, a blood test that measures prostate-specific antigen levels to screen for prostate cancer. Also known as prostate-specific antigen test, it’s one of the most common tools doctors use to check for prostate issues—but it’s far from perfect. Many men assume a high PSA reading means cancer, but that’s not always true. In fact, PSA test risks include false alarms, unnecessary biopsies, and even treatments for cancers that would never have caused harm.

One major issue is false positives, when PSA levels rise due to non-cancer causes like infection, enlargement, or even recent bike riding. A study in the New England Journal of Medicine found that nearly 75% of men with elevated PSA who had a biopsy didn’t have cancer. Then there’s overdiagnosis, the detection of slow-growing tumors that would never spread or affect lifespan. These cancers often lead to surgeries or radiation that come with serious side effects—like incontinence or impotence—without actually saving lives.

PSA levels also vary naturally. Age, race, medications, and even time of day can shift results. A man in his 60s might have a PSA of 4.5 and be perfectly healthy, while a 40-year-old with a PSA of 3.0 might need closer look. That’s why doctors now recommend shared decision-making: you and your provider weigh the risks and benefits based on your family history, symptoms, and personal values. The prostate health, a broader concept including screening, monitoring, and lifestyle factors that influence prostate function isn’t just about a number on a lab report.

What you’ll find below are real, practical guides that break down what PSA test risks really mean. You’ll see how false positives lead to unnecessary procedures, why some men choose to skip screening altogether, and what alternatives exist—like MRI scans or active surveillance. These aren’t theoretical opinions. They’re based on patient experiences, clinical data, and clear explanations of what happens next when your PSA comes back high. Whether you’re deciding whether to get tested, waiting for results, or trying to understand a diagnosis, these posts give you the facts without the hype.

PSA Screening Controversies: Why Shared Decision-Making Matters for Prostate Cancer

PSA Screening Controversies: Why Shared Decision-Making Matters for Prostate Cancer
7 November 2025 Shaun Franks

PSA screening for prostate cancer saves some lives but harms many more through overdiagnosis and overtreatment. Shared decision-making between patient and doctor is now the only ethical way to navigate this controversy.